Elimination and replenishment of tricarboxylic acid-cycle intermediates in myocardium

Tricarboxylic Acid Cycle in

Modification of pullorum disease in the chick by certain tricarboxylic acid cycle inhibitors and intermediates.

It is now known (Ross et al., 1955a, b, 1956) that the chick undergoes an altered protein metabolism when infected with Salmonella pullorum. This knowledge has suggested that the carbohydrate metabolism of the chick should also be investigated. In recent years, a number of agents such as radiation, war gases, hormones, drugs and certain adjuvants have been employed to hasten infection. Berry an...

Oxidation of fatty acids and tricarboxylic acid cycle intermediates by isolated rat liver mitochondria.

Beginning with the fundamental observation of Warburg in 1913 (1) it has been a general finding that the more highly organized enzyme systems of animal tissues responsible for oxidation of metabolites by molecular oxygen are associated with the insoluble particulate portion of the cell. Among the several approaches which have been used to study the morphology and composition of such catalytical...

Evidence for the occurrence of Permeases for tricarboxylic acid cycle intermediates in Pseudomonas aeruginosa.

Washed suspensions and cell-free extracts of Pseudomonas aeruginosa grown on Lemco agar, to which intermediates of the tricarboxylic acid cycle had been added, were tested for their ability to oxidize succinate, fumarate, malate, pyruvate, acetate, a-oxoglutarate and citrate. Whole organisms had lag periods of 2-3 hr. before citrate was oxidized rapidly, except when citrate or acetate had been ...

The oxidation of ethanol and tricarboxylic acid cycle intermediates by Acetobacter peroxydans.

The main taxonomic characteristic of the genus Acetobacter as presently described is the ability to oxidize ethanol to acetic acid (Breed et al., 1948), although some species carry the oxidation further. Of particular interest is the demonstration that Acetobacter aceti produces citrate when supplied acetate and intermediates of the TCA2 cycle (Antoniani et al., 1950). This species thus appears...